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KMID : 0670719980030010057
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Journal of the Korean Society Hyperthermia Oncology
1998 Volume.3 No. 1 p.57 ~ p.60
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The Multidisciplinary Treatment for Primary and Metastatic Tumors of the Liver
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Toshikazu Yoshikawa
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Abstract
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Back ground and Aim
We have found cytotoxicity and lipid peroxidation due to free radicals in cancer tissue
to represent a major mechanism of antitumor effect in hyperthermial. Three approaches
to enhance antitumor effect in hyperthermia may be considered; (a)strengthening radical
production itself; (b)increasing the substrate for the radical reaction; and (c) decreasing
the elimination of radicals. We try to enhance antitumor effect in hyperthermia using
granulocyte colony-stimulating factor (G-CSF) which increase leukocytes, the origin of
radicals, or 2, 2'-azobis (2-amidinopropane) dihydrochloride(AAPH) which generates free
radicals in a temperature-dependent manner, from the standpoint of (a). We used
Y-linolenic acid from the standpoint of (a). We used у-linolenic acid from the
standpoint of (b).
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KEYWORD
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